COOH-terminal fragment of APP interacts with p62, forms an

p62 is a well-characterized autophagy receptor that recognizes and sequesters specific cargoes into auto- phagosomes for degradation p62

In the present study, we analyzed the interaction between p62, an adapter protein, and an APP-related molecule, and found that p62 interacted with the C-

p62 com Upon binding to its ligand, p62 acts as a modulator of macroautophagy, inducing autophagosome biogenesis Through these dual functions, cells

p62 ทาง เข้า p62 expression leads to reduced deposition of Aβ42, Aβ40, and amyloid precursor protein in the hippocampus of the AD animal model